The resonance overlap and Hill stability criteria revisited
نویسندگان
چکیده
منابع مشابه
The Hill equation revisited: uses and misuses.
The Hill coefficient is commonly used to estimate the number of ligand molecules that are required to bind to a receptor to produce a functional effect. However, for a receptor with more than one ligand binding site, the Hill equation does not reflect a physically possible reaction scheme; only under the very specific condition of marked positive cooperativity does the Hill coefficient accurate...
متن کاملThe Chain Rule for HILL Pseudoentropy, Revisited
Computational notions of entropy (a.k.a. pseudoentropy) have found many applications, including leakage-resilient cryptography, deterministic encryption or memory delegation. The most important tools to argue about pseudoentropy are chain rules, which quantify by how much (in terms of quantity and quality) the pseudoentropy of a given random variable X decreases when conditioned on some other v...
متن کاملOverlap, comorbidity, and stability of somatoform disorders and the use of current versus lifetime criteria.
The authors examined disorder overlap, comorbidity, stability, and predictors of somatoform disorders (SDs) by "lifetime" and "current" symptom criteria in a general population sample of 421 respondents interviewed with the Composite International Diagnostic Interview in 1990 and 2001. Disorder overlap and comorbidity were considerable. "Current" SDs were four times more likely to occur among r...
متن کاملMaximum Contact Map Overlap Revisited
Among the measures for quantifying the similarity between three-dimensional (3D) protein structures, maximum contact map overlap (CMO) received sustained attention during the past decade. Despite this, the known algorithms exhibit modest performance and are not applicable for large-scale comparison. This article offers a clear advance in this respect. We present a new integer programming model ...
متن کاملTHEORY AND METHODS A philosophical analysis of the Hill criteria
The epidemiological literature contains an ongoing and diversified discussion of the Hill criteria. This article offers a philosophical analysis of the criteria, showing that the criteria are related to two different views of causality. The authors argue that the criteria of strength, specificity, consistency, experiment, and biological gradient are related to a probabilistic regularity view of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Celestial Mechanics and Dynamical Astronomy
سال: 2015
ISSN: 0923-2958,1572-9478
DOI: 10.1007/s10569-015-9646-z